Pigment dispersion in a case of Alport's syndrome.

The syndrome of hereditary nephritis and perceptive deafness was first recognized by Alport (1927), although reports suggestive of this association date from the latter part of the i8th century. The syndrome has since been widened to include certain ocular defects, such as lenticonus, microspherophakia, and lens opacities, and about IOO families have been described in the world literature. In recent years there have been several detailed reviews of the syndrome (Perkoff, Nugent, Dolowitz, Stephens, Carnes, and Tyler, 1958; Shaw and Glover, I96I; Crawfurd and Toghill, I968), including one of the ophthalmological findings (Arnott, Crawfurd, and Toghill, I966). This present report concerns a new family with previously unrecorded ocular defects.